you are: ILLNESS the CRONE

The disease Aetiology is unknown. The great value in patogeneze is given to the genetic factors, first of all genetically determined anomalies of function of nejtrofil th phagocytes which at illness the Crone possess lower, than at healthy, fagotsitarnoj by activity. Certain connection of disease with genetically caused markers - antigenes of the main complex gistosovmestimosti HLA is established. It is supposed, that at illness the Crone arises specific, assotsiirovannyj only with this disease an antigene having determinants with nativnym intestinal epiteliem. Autoimmunnye processes at illness the Crone get pathological character and lead to development of heavy system and local inflammatory reactions in mucous intestines.

Prominent feature of illness the Crone is ochagovoe defeat with accurate borders between the amazed and healthy sites. giperemirovannye, hilly, with moderated krovotochivostju sites alternate with a normal mucous membrane. In the beginning it is amazed podslizistyj a layer with gradual involving in process of muscular and subserous layers. The thickening and a hypostasis of an intestinal wall, formation granulem with epitelioidnymi the cages deprived kaze-oznoj of a basis are marked, lymphatic vessels are amazed. As a result the gut gleam is narrowed, fistulas, solderings, ulcers are formed.